The neurovascular coupling response of the aged brain is brain-state dependent.
Xiao Zhang, Lechan Tao, Amalie Holm Nygaard, Yiqiu Dong, Xiaoqi Hong, Carolyn Marie Goddard, Chen He, Dmitry D. Postnov, Ilary Allodi, Martin Lauritzen, Changsi Cai
This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.
bioRxiv · Jul 9, 2024 · PreprintNeuroscience