Dmitry D. Postnov

Sex shapes capillary flows and oxygen extraction in the middle-aged mouse brain

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

Pial arteries bend with every heartbeat

The paper shows that pial arteries in awake mice bend with each heartbeat, displacing walls more than three times the pulse-related dilatation, while veins show minimal movement.

Impaired Calcium Signaling in Precapillary Sphincters and Pericytes Perturbs Neurovascular Regulation after an Ischemic Stroke

This study investigates how impaired calcium signaling in precapillary sphincters and pericytes contributes to neurovascular uncoupling after ischemic stroke in mice.

Microvascular pulsatility of the ageing brain and confounding effects of anaesthesia

This study introduces a new method to measure microvascular pulsatility in mice and shows that anaesthesia alters pulsatility patterns, affecting the assessment of brain function.

Laser speckle contrast imaging of hepatic microcirculation

This study uses laser speckle contrast imaging to analyze hepatic microvascular blood flow in anesthetized rats, revealing flow oscillations and responses to Angiotensin-II.

The neurovascular coupling response of the aged brain is brain-state dependent.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.

SorCS2 modulates neurovascular coupling via glutamatergic and calcium signaling in astrocytes

This study shows that SorCS2 is critical for neurovascular coupling in mice through its role in glutamatergic and calcium signaling in astrocytes.

Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

The paper investigates how cell-type-specific neuronal activity affects oxygen consumption and blood flow in mouse somatosensory cortex, finding that CMRO2 responses depend on neuronal excitation rather than induced gamma activity.

Rapid disruption of the cortical microcirculation after mild traumatic brain injury

This study shows that mild traumatic brain injury rapidly disrupts cortical microcirculation, causing severe reductions in cerebral blood flow and vascular dysfunction.

Neutrophil-mediated dynamic capillary stalls in ischemic penumbra: persistent traffic jams after reperfusion contribute to injury

The paper identifies dynamic capillary flow stalls in mice after stroke reperfusion, mediated by neutrophils, which impair circulation and contribute to penumbral injury.