Synthetic BiologyNucleic Acids ResearchPeer-reviewed
Simple cloning of large natural product biosynthetic gene clusters from Streptomyces by an engineered CRISPR/Cas12a system
Mindong Liang, Leshi Liu, Fei Xu…·Gao‐Yi Tan
The paper develops a method to efficiently clone large GC-rich BGCs from Streptomyces genomes using a CRISPR/Cas12a-based system, demonstrating its effectiveness with a 87-kb BGC.
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