Author

Linquan Bai

Shanghai Jiao Tong UniversityORCID 0000-0002-3269-9747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Gao‐Yi TaniD· 2 shared Lixin ZhangiD· 2 shared Mindong Liang· 2 shared Weishan WangiD· 2 shared Biqin Chen· 1 shared Bozitao ZhongiD· 1 shared Dan LiiD· 1 shared Dongyuan LviD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMicrobiology

Gao‐Yi TanORCID

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3 papers

Recent·Most cited

Reaction-Conditioned Enzyme Discovery with Multimodal Deep Learning

Ziyi Zhou, Yutong Hu, Yuanzhen Zhang, Xinnan Fu, Runye Huang, Bozitao Zhong, Xiaoran Cheng, Jin Huang, Qin Xu, Shuangjun Lin, Linquan Bai, Liang Hong, Pan Tan

This paper introduces VenusRXN, a deep learning framework for reaction-conditioned enzyme discovery, achieving high accuracy in identifying enzymes for novel reactions.

bioRxiv · Mar 10, 2026 · PreprintSynthetic Biology

Enhancing and stabilizing a high-yield industrial Rhodobacter sphaeroides strain for coenzyme Q10 production

Mindong Liang, Xinwei He, Dongyuan Lv, Jing Liu, Kefeng Wang, Yingrui Hou, Weishan Wang, Linquan Bai, Guang Liu, Zhichun Zhu, Dan Li, Biqin Chen, Lixin Zhang, Gao‐Yi Tan

This paper enhances CoQ10 production in Rhodobacter sphaeroides by engineering the PrrAB system and stabilizing the strain through CRISPRi, achieving 3.6 g/L in pilot-scale fermentation.

bioRxiv · Jul 16, 2025 · PreprintMicrobiology

Simple cloning of large natural product biosynthetic gene clusters from Streptomyces by an engineered CRISPR/Cas12a system

Mindong Liang, Leshi Liu, Fei Xu, Xiaoqian Zeng, Ruijun Wang, Yang Jinling, Weishan Wang, Loganathan Karthik, Jiakun Liu, Zhiheng Yang, Guoliang Zhu, Shuliu Wang, Linquan Bai, Yaojun Tong, Xueting Liu, , Gao‐Yi Tan

The paper develops a method to efficiently clone large GC-rich BGCs from Streptomyces genomes using a CRISPR/Cas12a-based system, demonstrating its effectiveness with a 87-kb BGC.

Nucleic Acids Research · Mar 10, 2022Peer-reviewedSynthetic Biology