Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice
Natalie Eppler, Elizabeth Jones, Forkan Ahamed, Naren Raja, Jephte Yao Akakpo, Margitta Lebofsky, Lily He, Ira Vats, Priyanka Ghosh, Yifan Yu, Kaitlyn Thomas, Colin S. McCoin, John Thyfault, Xiaoqing Wu, Liang Xu, , Yuxia Zhang
This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.
Toxicology · Apr 30, 2026Peer-reviewedPharmacology & Toxicology