Colin S. McCoin

Brca1 heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolism

This study shows that Brca1 heterozygosity causes hepatic steatosis in both male and female mice on a high-fat diet, despite sex differences in systemic metabolic outcomes.

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.

Hepatocyte Estrogen Receptor α Mediates Estrogen-induced Augmentation of Hepatic 1 Mitochondrial Respiration Following Ovariectomy.

This study shows that estrogen receptor α in hepatocytes is necessary for estrogen to enhance mitochondrial respiration and reduce steatosis after ovariectomy.

Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms

This study characterizes the CRY1 R263Q mutation in subterranean animals, showing altered circadian rhythms and gene expression in mice, but no major metabolic defects.