A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing
Siyuan Dai, Xiaoyin Tang, Lili Li, Takao Ishidate, Ahmet Rasit Ozturk, Hao Chen, Altair L. Dube, Yonghong Yan, Meng‐Qiu Dong, En-Zhi Shen, Craig C. Mello
This study identifies GLH proteins' role in controlling Argonaute pathway specificity and promoting transgenerational silencing in C. elegans by binding to target mRNAs and amplifying small RNAs.
Cell Reports · Sep 1, 2022Peer-reviewedMolecular Biology