Author
Westlake UniversityORCID 0000-0002-6095-7803Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jake Leyhr, Qiuyi Chi, Lin Zeng, En-Zhi Shen, Wei Zou, David R. Sherwood
The paper catalogs endogenously tagged proteins in C. elegans, identifies gaps in coverage, and provides a database with tools for designing knock-in experiments.
bioRxiv · Dec 5, 2025 · PreprintGenetics
Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, , En-Zhi Shen
This study reveals structural and functional features of mammalian PIWI-piRNA-target complexes that enable efficient and broad target silencing.
Nature Structural & Molecular Biology · Apr 24, 2024Peer-reviewedMolecular Biology
Siyuan Dai, Xiaoyin Tang, Lili Li, Takao Ishidate, Ahmet Rasit Ozturk, Hao Chen, Altair L. Dube, Yonghong Yan, Meng‐Qiu Dong, En-Zhi Shen, Craig C. Mello
This study identifies GLH proteins' role in controlling Argonaute pathway specificity and promoting transgenerational silencing in C. elegans by binding to target mRNAs and amplifying small RNAs.
Cell Reports · Sep 1, 2022Peer-reviewedMolecular Biology
En-Zhi Shen, Hao Chen, Ahmet Rasit Ozturk, Shikui Tu, Masaki Shirayama, Wen Tang, Yue‐He Ding, Siyuan Dai, Zhiping Weng, Craig C. Mello
The paper identifies piRNA binding sites in C. elegans germline mRNAs and shows piRNA targeting follows microRNA-like rules, with binding energy more important than piRNA abundance.
Cell · Feb 1, 2018Peer-reviewedGenetics