Author

Yonghong Yan

National Institute of Biological Sciences, Beijing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Cell Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 5 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Meng‐Qiu DongiD· 5 shared Chenchun WengiD· 2 shared Chenming Zeng· 2 shared Craig C. MelloiD· 2 shared Shouhong GuangiD· 2 shared Wen-Jun LiiD· 2 shared Xuezhu FengiD· 2 shared Ahmet Can BerkyurekiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMolecular Biology

Meng‐Qiu DongORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

Jimmy H. Mo, Chao Zhai, Kwangsek Jung, Yan Li, Yonghong Yan, Meng‐Qiu Dong, Ho Yi Mak

This study identifies TNGL-1 as a C. elegans TANGO1 family member that facilitates vitellogenin export from the ER by engaging cargo via a luminal domain.

iScience · Jan 20, 2025Peer-reviewedCell Biology

A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

Siyuan Dai, Xiaoyin Tang, Lili Li, Takao Ishidate, Ahmet Rasit Ozturk, Hao Chen, Altair L. Dube, Yonghong Yan, Meng‐Qiu Dong, En-Zhi Shen, Craig C. Mello

This study identifies GLH proteins' role in controlling Argonaute pathway specificity and promoting transgenerational silencing in C. elegans by binding to target mRNAs and amplifying small RNAs.

Cell Reports · Sep 1, 2022Peer-reviewedMolecular Biology

HDAC1 SUMOylation promotes Argonaute directed transcriptional silencing in C. elegans

Heesun Kim, Yue‐He Ding, Gangming Zhang, Yonghong Yan, Darryl Conte, Meng‐Qiu Dong, Craig C. Mello

This study shows that SUMOylation of HDA-1 in C. elegans is required for Argonaute-directed transcriptional silencing by facilitating interactions with the NuRD complex and nuclear Argonaute HRDE-1/WAGO-9.

eLife · May 17, 2021Peer-reviewedMolecular Biology

Differential phase partition of a PICS complex is required for piRNA processing and chromosome segregation in C. elegans

Chenming Zeng, Chenchun Weng, Xiaoyang Wang, Yonghong Yan, Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Xuezhu Feng, Meng‐Qiu Dong, Chao Xu, Shouhong Guang

The paper identifies a PICS complex involved in piRNA processing and chromosome segregation in C. elegans, with distinct localization and function in different cellular contexts.

bioRxiv · Nov 6, 2018 · PreprintGenetics

The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans

Chenchun Weng, Asia Kosalka, Ahmet Can Berkyurek, Przemysław Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yonghong Yan, Meng‐Qiu Dong, Cecilia Zuliani, O. Barábas, Julie Ahringer, Shouhong Guang, Eric Alexander Miska

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

bioRxiv · Jul 30, 2018Developmental Biology