Dynamic architecture of the Rixosome reveals mechanism of activation and ITS2 processing
Matthias Thoms, Jingyi Zhu, Xiaying Hong, Timo Denk, Jingzhi Stritzel, Shuangshuang Niu, Otto Berninghausen, Yi Li, Jiaxian Liu, Roland Beckmann, Jingdong Cheng
The paper presents cryo-EM structures of the Rixosome and pre-60S particles to elucidate the dynamic architecture and activation mechanism of the Rixosome for ITS2 processing.
bioRxiv · Sep 14, 2026 · PreprintBiochemistry