Roland Beckmann

The paper presents cryo-EM structures of the Rixosome and pre-60S particles to elucidate the dynamic architecture and activation mechanism of the Rixosome for ITS2 processing.

The paper shows that different drugs inducing ribosome collisions lead to distinct cellular responses through varied signaling pathways and structural changes in ribosomes.

This study identifies Drs1 as a key RNA helicase that facilitates the incorporation of 25S rRNA domain III during early pre-60S ribosome maturation by interacting with Erb1 and remodeling pre-rRNA.

This study shows that yeast Dhx29 unwinds structured mRNA in the ribosomal A-site during translation elongation, resolving hairpin structures and preventing ribosome collisions.

The paper examines the structure and function of the PelBC export complex in Pseudomonas aeruginosa, showing how it stabilizes outer membrane lipids and guides polysaccharide export.

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

The paper identifies Sni445 as a novel factor that recruits snR4 and snR45 snoRNPs to 90S pre-ribosomes, enabling Kre33-mediated acetylation of 18S rRNA.

This study determines the structure of the PelBC exopolysaccharide transporter in Pseudomonas aeruginosa and identifies its gating mechanism for exopolysaccharide transport.

The paper visualizes the biogenesis of a bacterial membrane protein using cryo-EM and cell-free synthesis, revealing a gate-independent insertion mechanism involving SecYEG and YidC.

The paper shows that the H/ACA snoRNP snR30 forms a satellite particle to guide 18S rRNA subdomain folding before integrating into the 90S pre-ribosome, enhancing ribosome assembly accuracy.

The paper shows that HrpA, an RNA helicase in E. coli, rescues stalled ribosomes by splitting collided ribosomes into subunits using ATP hydrolysis.

This study shows that MutS2 in B. subtilis splits stalled ribosomes into subunits without cleaving mRNA, differing from the E. coli SmrB mechanism.

The paper identifies Otu2's role in deubiquitinating eS7 on recycled 40S ribosomal subunits to reset translation, revealing structural mechanisms for this process.

The paper identifies SmrB as a factor that cleaves mRNAs upstream of stalled ribosomes in bacteria, promoting ribosome rescue through ribosome collisions.

The paper uses cryo-EM to characterize native ABCE1-containing pre-initiation complexes in yeast and human cells, revealing their structural roles in translation initiation.

The paper presents cryo-EM structures of hibernating yeast and human ribosomes, showing Lso2/CCDC124 binds in a non-rotated state, enabling rapid translation reactivation.

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.

The paper shows the Ccr4-Not complex interacts with the ribosome's E-site when codon optimality is low, linking translation efficiency to mRNA stability.

The paper presents cryo-EM structures of hibernating 70S and 100S ribosomes from E. coli, revealing the roles of HPF and RMF in ribosome inactivation and dimerization.