Jingdong Cheng

The paper presents cryo-EM structures of the Rixosome and pre-60S particles to elucidate the dynamic architecture and activation mechanism of the Rixosome for ITS2 processing.

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

This study identifies DSS1 as an essential subunit of the INTAC complex, showing its role in stabilizing INTAC and its impact on transcriptional regulation.

This study shows LARP1 binds free ribosomal subunits to repress TOP mRNAs, coordinating ribosome protein synthesis with cellular demand.

The paper determines the structure of the PEC-INTAC complex and shows how INTAC facilitates RNA cleavage and CTD dephosphorylation during transcription termination.

The paper identifies Otu2's role in deubiquitinating eS7 on recycled 40S ribosomal subunits to reset translation, revealing structural mechanisms for this process.

The paper uses cryo-EM to characterize native ABCE1-containing pre-initiation complexes in yeast and human cells, revealing their structural roles in translation initiation.

The paper presents cryo-EM structures of hibernating yeast and human ribosomes, showing Lso2/CCDC124 binds in a non-rotated state, enabling rapid translation reactivation.

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.

The paper shows the Ccr4-Not complex interacts with the ribosome's E-site when codon optimality is low, linking translation efficiency to mRNA stability.