Timo Denk

Dynamic architecture of the Rixosome reveals mechanism of activation and ITS2 processing

The paper presents cryo-EM structures of the Rixosome and pre-60S particles to elucidate the dynamic architecture and activation mechanism of the Rixosome for ITS2 processing.

Conformational diversity of collided ribosomes determines stress signaling

The paper shows that different drugs inducing ribosome collisions lead to distinct cellular responses through varied signaling pathways and structural changes in ribosomes.

RNA helicase Drs1 gates 25S rRNA domain III incorporation during early nucleolar pre-60S maturation

This study identifies Drs1 as a key RNA helicase that facilitates the incorporation of 25S rRNA domain III during early pre-60S ribosome maturation by interacting with Erb1 and remodeling pre-rRNA.

Yeast Dhx29 promotes translation progression by unwinding structured mRNA in the ribosomal A-site

This study shows that yeast Dhx29 unwinds structured mRNA in the ribosomal A-site during translation elongation, resolving hairpin structures and preventing ribosome collisions.

A bifunctional H/ACA snoRNP mediates both pseudouridylation and rRNA scaffolding during ribosome assembly

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

H/ACA snoRNP guides ribosomal RNA subdomain folding in a satellite particle before joining the core 90S pre-ribosome

The paper shows that the H/ACA snoRNP snR30 forms a satellite particle to guide 18S rRNA subdomain folding before integrating into the 90S pre-ribosome, enhancing ribosome assembly accuracy.

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.