Gloria Pryhuber

This study shows that SARS-CoV-2 defective viral genomes from different genomic hotspots induce divergent interferon responses, with hotspot B DVGs strongly stimulating IFN responses and hotspot A DVGs not.

The paper introduces RomicsProcessor, a reproducible-by-design tool for multi-omics and spatial-omics analysis that enforces FAIR principles and ensures computational reproducibility.

The paper identifies region-specific molecular regulatory programs in human distal airways that maintain epithelial identity and mucus homeostasis, revealing mechanisms for mucociliary defense.

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

FUSION is a web-based tool that integrates spatial -omics data with histology to analyze tissue states and identify spatial linkages between molecular and histopathologic features.

The paper analyzes endothelial cell environments across organs using spatially resolved omics data and provides an interactive tool for visualizing cell distances and neighborhoods.

This study uses sorted-cell proteomics to identify BPD-specific proteome changes in epithelial and endothelial cells, revealing cornification-associated proteins and redox imbalance.

This paper introduces DeepSAS, a deep graph framework to identify senescent cells and their associated genes, revealing cell-type-specific senescence features in aging and disease.

This paper presents a multimodal imaging approach to characterize metabolic changes in bronchopulmonary dysplasia, revealing altered lipid distributions and collagen remodeling in affected tissues.

This paper constructs a 3D map of neurovascular nephron connectivity in the human kidney across the lifespan and identifies structural changes in development and disease.

The paper creates a high-resolution multimodal lung atlas using single-nucleus RNA and chromatin data from 11 healthy adults, identifying 70 cell populations and 332,846 chromatin regions.

The paper integrates N-glycan analysis with CODEX imaging to identify cell-specific glycosylation patterns in healthy human lung tissue.

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

NS-Forest v4.0 identifies optimal marker genes for cell type classification in scRNA-seq data, improving accuracy and selectivity for closely related cell types.

The paper uses single-cell RNA sequencing to create a molecular map of newborn human lung cells and identifies cell type-specific developmental states and biomarkers.

This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

The paper describes the LungMAP Portal Ecosystem, a centralized resource integrating multi-omics and imaging data across species to enable standardized analysis of lung biology and disease.

The paper profiles the transcriptional development and injury sensitivity of lung endothelial subtypes during postnatal growth, revealing distinct transcriptomic changes and differential responses to hyperoxia.

This study shows that neonatal hyperoxia inhibits atrial cardiomyocyte proliferation by suppressing fatty acid synthesis genes, leading to diastolic heart failure.

The paper identifies gene expression patterns in CD8+ T cells associated with BPD and PRD in preterm infants using transcriptomic data from the PROP cohort.

The paper uses single nucleus ATAC-seq and RNA-seq to show age-related changes in chromatin accessibility and gene expression linked to SARS-CoV-2 entry genes in human lung cells.

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

The paper examines co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year, identifying three patterns of CST manifestation related to infant maturity.