Author

Xin Chai

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Baidong HouiD· 1 shared Chang GuoiD· 1 shared Fangqing ZhaoiD· 1 shared Fuping ZhangiD· 1 shared Jie Fang GuoiD· 1 shared Li LiiD· 1 shared Qiuzhu Jin· 1 shared Ruiqiao He· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Baidong HouORCID

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1 paper

Recent·Most cited

TCR signal strength determines Treg instability and discrimination of self versus non-self antigens

Li Li, Jie Fang Guo, Ruiqiao He, Xin Chai, Chang Guo, Wei Xu, Xue Li Cao, Qiuzhu Jin, Fuping Zhang, Baidong Hou, Fangqing Zhao, Xuyu Zhou

The paper shows that strong TCR signals from foreign antigens destabilize Tregs, converting them into effector-like cells, while self-antigens preserve stability, revealing a mechanism for balancing immunity and tolerance.

bioRxiv · Feb 14, 2026 · PreprintImmunology