Wei Xu

The paper shows that strong TCR signals from foreign antigens destabilize Tregs, converting them into effector-like cells, while self-antigens preserve stability, revealing a mechanism for balancing immunity and tolerance.

This paper uses N-glycoproteomics to analyze patient-derived xenografts, identifies FAT2 as a therapeutic target for head and neck cancers, and validates its role in tumor growth and CAR T cell activity.

The paper introduces memo-eQTL, a method to identify DNA methylation-modulated eQTLs, and finds 1,731 novel memo-eQTLs in prostate samples that alter SNP-gene expression interactions through CTCF-based chromatin structure changes.

The paper introduces a two-stage multivariate Mendelian Randomization method to analyze mixed distributed outcomes with instrumental variables, showing improved statistical power in simulations and a clinical trial.

This study investigates how morphine affects the 3D chromatin architecture of primate cortical neurons using DLO Hi-C, finding significant changes in chromosome territories, TADs, and differential loops.

The paper identifies dysfunction of the paraventricular hypothalamic nucleus (PVH) as a cause of hypersomnia in humans and mice through neural activity and behavioral studies.