Macrophages promote collagen deposition through circadian regulation of fibroblasts
Katherine Lowles, Xin-Yang Zhang, Xuefeng Yao, Marie F.A. Cutiongco, Joshua J. Hughes, Shi-Yang Li, John Knox, Madeleine Coy, Wei‐Hsiang Lin, Andrew S. MacDonald, Karl E. Kadler, Qing‐Jun Meng, Tracy Hussell, Joan Chang
This study shows macrophages enhance collagen deposition in fibroblasts through circadian regulation, with M2 macrophages using PDGFA to strengthen circadian rhythms and increase collagen production.
iScience · Sep 21, 2026Peer-reviewedCell Biology