Joan Chang

Macrophages promote collagen deposition through circadian regulation of fibroblasts

This study shows macrophages enhance collagen deposition in fibroblasts through circadian regulation, with M2 macrophages using PDGFA to strengthen circadian rhythms and increase collagen production.

Ageing impacts extracellular matrix turnover and remodelling in the kidney

This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

Loss of lmx1ba drives premature osteoarthritis through disruption of skeletal homeostasis

This study shows that loss of lmx1ba in zebrafish causes premature osteoarthritis by disrupting skeletal homeostasis and joint maintenance in adult life.

Circadian and permanent pools of extracellular matrix co-exist in tendon tissue, but have distinct rates of turnover and differential responses to ageing

The paper uses stable isotope labeling and mass spectrometry to show that tendon ECM has circadian and permanent pools with distinct turnover rates, which change with age.

Collagen assembly and turnover imaged with a CRISPR-Cas9 engineered Dendra2 tag

The paper uses CRISPR-Cas9 to tag collagen-I with Dendra2 for live imaging, showing cells synthesize, migrate on, and interact with collagen fibrils.