Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer's tau pathology and uncover human-specific neuronal vulnerability
Yanru Ji, Purba Mandal, Jiahui Liu, Wen Hu, Bryce David Colon, Changlin Wan, Raymond W. Pan, Dongkai Guo, Lijia Zhang, Xingjian Gu, Yang Yang, Kun Huang, Riyi Shi, Chao Qi, Chongli Yuan, , Ranjie Xu
This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience