Purba Mandal

This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.

The paper identifies preserved mitochondrial bioenergetics in asymptomatic Alzheimer's disease brains and suggests NAD+ precursor interventions could maintain cognitive function despite pathology.

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.