Ranjie Xu

This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.

This study uses vascularized neuroimmune organoids to model sporadic Alzheimer's disease and test drug efficacy.

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

The paper investigates the impact of the NLGN3 R451C mutation on human neurons, finding it reduces protein levels but enhances excitatory synapses, potentially contributing to ASD pathogenesis.

This study develops a human brain organoid model with controllable microglia ratios to better model brain development and pathology.

This study xenotransplants human PSC-derived microglia into mice to create a chimeric brain model that retains human microglial identity and exhibits disease-relevant responses.

This study shows that OLIG2 overexpression in Down syndrome patient-derived iPSCs leads to abnormal neurodevelopmental phenotypes, including impaired recognition memory in chimeric mice.

This study uses human pluripotent stem cell-derived cerebral organoids to show that oligodendrogenesis in the human brain has both ventral and dorsal origins, with dorsal cells dominating in fused organoids.