Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie‐Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.
Cell Reports · Mar 1, 2022Peer-reviewedNeuroscience