Marie‐Ève Tremblay

The paper introduces a CellProfiler pipeline for automated clustering of microglial morphology using hierarchical and k-means methods, enabling user-friendly analysis of morphological subgroups.

This study examines how different cannabis THC:CBD compositions affect oligodendrocyte progenitor cells in mice after acute vapor inhalation, finding morphological and mitochondrial changes similar to early differentiation.

This paper introduces a semi-automated CellProfiler framework for quantifying microglial density, distribution, and morphology, improving accuracy over fully automated or manual methods.

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

The paper identifies neuronal lipid droplets as conserved structures that regulate energy homeostasis with sex-biased effects in flies and mice.

This study shows clozapine reduces anti-NMDAR autoantibodies and psychosis-like behaviors in mice by suppressing autoimmunity.

This study examines early microglial responses to FUS-induced BBB modulation, finding no significant density changes but increased cell elongation and altered synaptic interactions.

This study examines the effects of prenatal THC exposure on mouse brain development using MRI across the lifespan, finding sex-dependent neurodevelopmental impacts.

This study shows that adolescent stress impairs parvalbumin interneurons and perineuronal nets, but minocycline treatment prevents these effects in adult mice.

This study compares 2D and 3D image analysis of microglial morphology in mouse brains, finding similar and novel results, consistent conclusions, and the importance of nested statistical designs.

The paper quantifies astrogliosis in a Syrian hamster model of mild-moderate COVID-19, finding a transient, female-specific increase in GFAP signal density in the cortex at 3 days post-inoculation.

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

This study investigates the role of CLEC7A-positive microglia and dark microglia in a mouse model of Parkinson's disease with the LRRK2 G2019S mutation, revealing their association with cellular stress and pathology.

This study shows that a ketogenic diet promotes resistance to stress in mice by altering microglial morphology and lipid profiles in the hippocampus, with distinct effects in stress-susceptible and resistant mice.

This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.

This study examines how early or late prenatal maternal immune activation affects mouse embryo brain development, finding distinct neuroanatomical changes depending on exposure timing.

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

This study shows that microglia regulate glutamatergic synapses in adult mouse hippocampus, with their removal causing reversible synaptic and behavioral changes.

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.

The paper shows that repeated stress reduces intrinsic excitability of HPA axis neurons through increased cell size and membrane area, challenging conventional views on excitability plasticity.

This study identifies the cell-lineage specific localization of primary cilia in the epididymis during post-natal development and confirms their association with disease-related proteins.