Jessica L. Bolton

This study shows that early-life adversity increases IL-17A levels in female mice blood, linking it to autoimmune disease risk, while also affecting other proteins in both sexes.

This study examines the effects of constitutive CX3CR1-BAC-Cre expression on microglia and finds minimal off-target effects compared to tamoxifen-induced models.

The paper identifies that a goat anti-Iba1 antibody labels vasopressin neurons in mice, not microglia, highlighting the need for antibody validation.

This study examines sex differences in blood pressure, autonomic activity, and inflammation in rats exposed to a low resource environment during early life, finding increased BP in males and potential protective effects in females.

This study shows mismatch negativity matures in adolescence in mice and its development does not require microglia activity.

This study shows that ELA increases excitatory synapses in male mice's PVN by inhibiting microglial MerTK, mimicked by microglial MerTK deletion, but not in females.

This study examines how maternal diesel exposure and choline supplementation interact to affect fetal and placental immune factors, revealing region- and sex-specific effects on inflammation and microglial morphology.

The paper shows maternal high-fat diet affects placenta-brain communication differently in male and female offspring, leading to sex-specific behavioral and serotonin-related changes.

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

This study uses single-cell RNA sequencing to identify lasting transcriptional changes in hypothalamic CRH-expressing neurons after early-life adversity, linking these changes to long-term stress responses.

This study investigates how early-life adversity affects vulnerability to opioid addiction in rats, finding that it leads to addiction-like behaviors and altered reward circuitry.

The paper uses intra-individual DNA methylation analysis in rat buccal cells to show that early-life adversity alters methylation patterns predictive of gene repression and upregulation of inflammation and cell-fate pathways.