NeuroscienceCell ReportsPeer-reviewed
Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy…·Tallie Z. Baram
The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.
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