Shivashankar Othy

This study uses spatial transcriptomics to show that immune checkpoint inhibitors activate microglia via T cell interactions, leading to neuroinflammation and synaptic dysfunction in the brain.

This study shows that combination immune checkpoint inhibition disrupts CNS neuro-immune homeostasis, activates microglia, and causes long-term cognitive impairments in a murine melanoma model.

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.