Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy
Shenzhi Zhou, Xingyu Ji, Hanfeng Lin, Denise G. Lanza, Sung Y. Jung, Jun Liu, Ashish Dogra, Behnam Nabet, Kevin R. MacKenzie, Jin Wang, Martin Matthew Matzuk, Feng Li
This paper introduces a method to reversibly regulate CYP1A2 enzyme activity in mice using a dTAG knock-in strategy, demonstrating its utility in drug metabolism studies.
bioRxiv · May 12, 2026 · PreprintPharmacology & Toxicology