Kevin R. MacKenzie

This paper introduces a method to reversibly regulate CYP1A2 enzyme activity in mice using a dTAG knock-in strategy, demonstrating its utility in drug metabolism studies.

SPA-STOCSY is an automated tool for identifying annotated and non-annotated metabolites in NMR spectra, showing high accuracy and efficiency in both synthetic and real data.

This study identifies oleic acid as a ligand for TLX/NR2E1 that promotes hippocampal neurogenesis by converting TLX from a repressor to an activator of cell cycle and neurogenesis genes.