Martin Matthew Matzuk

Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy

This paper introduces a method to reversibly regulate CYP1A2 enzyme activity in mice using a dTAG knock-in strategy, demonstrating its utility in drug metabolism studies.

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

This study identifies SLC35G3 as a UDP-GlcNAc transporter essential for sperm glycoprotein formation and male fertility in mice.

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

The paper uses affinity-tagged SMAD1 and SMAD5 mouse lines to study their roles in endometrial decidualization during early pregnancy, revealing their genomic binding patterns and functional impact on decidual marker expression.

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

The paper shows that sperm cooperation in mice forms clusters at the utero-tubal junction, facilitating oviduct entry and fertilization, with defects in this process linked to infertility.