Enhancing precision medicine for patients with breast cancer brain metastases through functional drug testing
Ellen Wold, Nathan M. Merrill, Habib A. Serhan, Aaron M. Udager, Chia Jen Liu, Ning Gu, Liwei Bao, Zhaoping Qin, Xu Cheng, Peter Ulintz, Jason A. Heth, Matthew B. Soellner, Sofia D. Merajver, Aki Morikawa
This study uses patient-derived organoids to test drug responses in breast cancer brain metastases, showing subtype-specific variations and the potential of PI3K inhibitors regardless of PIK3CA mutation status.
bioRxiv · Apr 22, 2026 · PreprintCancer Biology