Exercise training improves exercise capacity independent of AMPKa2 T172-mediated adaptations in skeletal muscle
Xuansong Mao, Ryan N. Montalvo, Kenya Takahashi, Frank W. Booth, George A. Brooks, Zhen Yan
This study shows that AMPK2 T172 activation is necessary for mitochondrial and angiogenic adaptations in skeletal muscle from exercise training, but not for improved exercise capacity.
bioRxiv · Jun 23, 2026 · PreprintPhysiology