Matthew J. Gaffrey

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This paper introduces an improved single-cell proteomics method, iSOP-MS, which enhances robustness and convenience for quantitative analysis by using a low-volume 384-well plate and optimized enzyme mixtures.

This paper develops a dual ion funnel interface to enhance sensitivity in single-cell proteomics, enabling reliable quantification of low-abundance proteins from single-cell samples.

This study shows that activating AMPK alpha2 T172 in skeletal muscle improves exercise performance and energy transduction, and its disruption mimics type 2 diabetes features.

This study shows that m6A methylation, regulated by METTL3, controls the innate immune response in β-cells during T1D onset by modulating OAS mRNA stability.