Zhen Yan

This study shows that AMPK2 T172 activation is necessary for mitochondrial and angiogenic adaptations in skeletal muscle from exercise training, but not for improved exercise capacity.

This study shows that increasing neuronal MCU in the hippocampus improves mitochondrial calcium uptake and respiratory efficiency in response to energy demand.

This study shows that activating AMPK alpha2 T172 in skeletal muscle improves exercise performance and energy transduction, and its disruption mimics type 2 diabetes features.

AAV9-PERM1 gene therapy preserves cardiac function in a mouse model of pressure overload-induced heart failure by maintaining mitochondrial biogenesis, respiration, and contractility.