Han Zhang

Novel Dissymmetric Ionizable Lipid-Assembled Lipid Nanoparticles for Delivery of Ferroptosis-Related siRNA in Diabetic Treatment

This study develops novel dissymmetric ionizable lipid nanoparticles for delivering ferroptosis-related siRNA, showing improved therapeutic effects in diabetic models.

A transcriptome map reveals conserved and lineage-specific sRNAs that regulate motility and metabolism across Vibrio

The paper maps sRNAs in Vibrio parahaemolyticus, identifies conserved and lineage-specific sRNAs, and shows their roles in regulating motility and metabolism.

A multi-agent system for spine MRI report generation from multi-sequence imaging

SpineAgent generates spine MRI reports by integrating multi-sequence data using a multi-agent framework, achieving state-of-the-art performance and strong generalizability.

Genetic loss of JAK1 and cutaneous HPV infection

The paper identifies JAK1 loss-of-function variants in patients with epidermodysplasia verruciformis, linking them to susceptibility to cutaneous HPV infection and impaired antiviral immunity.

Autolamellasomes: Linking Autophagy-Dependent ER Degradation to Whorled Lysosome Biogenesis

The paper identifies autolamellasomes as a form of ER remodeling mediating bulk ER degradation under mTOR inhibition, linking it to lysosomal membrane homeostasis and aging.

MetaFold-RNA: Accurate prediction of RNA secondary structure using a meta-learning-guided deep network

MetaFold-RNA improves RNA secondary structure prediction using a meta-learning framework, achieving state-of-the-art results on unseen RNA families.

Percent amplitude of fluctuation: a simple measure for resting-state fMRI signal at single voxel level

The paper introduces PerAF, a new standardized metric for RS-fMRI that improves reliability and provides clearer insights into resting-state brain activity compared to existing methods like ALFF and fALFF.

The STROBE: a system for closed-looped optogenetic control of freely feeding flies

The paper introduces STROBE, a closed-loop optogenetic system for controlling feeding behavior in Drosophila, showing it can drive attraction or avoidance based on sensory neuron activation.