Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells
Qi Zhang, Yunfeng Wang, Xueli Fu, Ziguang Wang, Yang Zhang, Lizhong Yan, Yuejia Wang, Muhan Yang, Dan Song, Ruixing Zhang, Hongru Zhang, Shian Wu, Shaowei Zhao
The paper identifies Uev1A and its human homologs as protectors against oncogenic Ras-induced cellular stress in both polyploid and diploid cells, showing their role in suppressing tumor growth and improving patient survival.
bioRxiv · Apr 17, 2025Cell Biology