Self-limiting population suppression gene drive in the West Nile vector mosquito, Culex quinquefasciatus
Xuechun Feng, Jinying Ding, Yiran Liu, Víctor López Del Amo, Valentino Matteo Gantz, Xuexin Chen, Jackson Champer, Feng Liu
This paper describes a CRISPR-based gene drive targeting the doublesex gene in Culex mosquitoes to suppress populations through male-biased propagation and sterile intersexes.
bioRxiv · Jul 16, 2025 · PreprintGenetics