Jackson Champer

This study evaluates Cas9 fusion proteins in Drosophila to enhance homing gene drive performance by improving HDR and reducing resistance.

The paper identifies 3'UTR regulatory elements using synthetic inserts and a deep learning model, revealing their effects on gene expression and nuclear-cytoplasmic partitioning, and highlights disease-relevant variants.

This study evaluates CRISPR toxin-antidote gene drives in spatially structured populations, finding that confinement depends on drive type and ecological factors.

This paper develops a 2-locus CRISPR toxin-antidote gene drive system that improves confinement by increasing the introduction threshold for population modification.

This study evaluates how guide RNA multiplexing and target site selection affect homing gene drive efficiency in Drosophila suzukii, showing that germline context and design choices significantly influence performance.

The paper develops a hexagon-based model to simulate gene drive spread and evaluates optimal release patterns for different scenarios.

This study shows that CRISPR-based gene drives producing dominant female-sterile alleles can enhance population suppression by increasing elimination rates and reducing chasing dynamics.

The paper develops a confined gene drive system called TARE in Anopheles stephensi to modify mosquito populations, showing it can spread but faces challenges from fitness costs and resistance.

This study develops a modeling framework for gene drives in plants that includes soil seedbanks, showing how seedbanks can slow spread but reduce genetic load and provide biosafety.

This study identifies optimal spatial release strategies for gene drives and Wolbachia to maximize per-capita efficiency across different drive types and timeframes.

This study uses a simulation-based deep learning model to analyze how different parameters affect mosquito suppression and malaria prevalence in Anopheles gambiae.

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.

This study evaluates strategies to improve homing gene drive efficiency using multiplexed gRNAs, finding that population-level multiplexing enhances drive efficiency despite increased vulnerability to resistance.

The paper introduces YYAP, an engineered gene drive system that enforces obligate co-inheritance of alleles, demonstrating efficient population replacement and suppression in Drosophila.

The paper investigates how modifying Cas9 regulatory elements affects gene drive performance in Drosophila, finding that promoter truncation reduces resistance allele formation but decreases germline cutting efficiency.

This study models gene drive strategies for controlling fire ants, finding that suppression drives can effectively eliminate polygyne colonies but require specialized approaches to target monogyne populations.

The paper correlates single-cell transcriptome data with gene drive performance by analyzing Cas9 promoter expression in different systems.

This study demonstrates daisy chain gene drives in Drosophila and models their population dynamics, finding they can eliminate populations but face challenges in efficiency and spread.

This paper describes a CRISPR-based gene drive targeting the doublesex gene in Culex mosquitoes to suppress populations through male-biased propagation and sterile intersexes.

This study tests a homing gene drive in Drosophila melanogaster and finds that while simple resistance alleles can emerge, complex resistance is unlikely due to no heritable genetic effects on drive efficiency.

This paper describes a gene drive targeting doublesex in Drosophila that generates dominant female-sterile resistance alleles, leading to stronger population suppression in computational models.

This study identifies APN3 as a functional receptor for Cry4Ba toxin in Aedes aegypti, showing its role in toxin binding and larvicidal activity through genetic knockout experiments.

This study compares self-limiting genetic control strategies for pest population suppression using simulations, finding some are safer, more flexible, and cost-effective than traditional methods.

The paper develops a split-CRISPR/Cas9 system for sex conversion in Mediterranean fruit flies to improve population control strategies.

This paper introduces a two-target gene drive design that improves suppression efficiency by combining homing and fitness cost elements, showing success in Drosophila but highlighting remaining challenges.

This study evaluates the efficiency and resistance allele formation of two CRISPR/Cas9-based gene drives in Aedes aegypti, finding one drive achieves super-Mendelian inheritance rates.

The paper investigates the deployment of tethered gene drives in continuous space, finding that drive wave interference must be avoided to ensure successful suppression.

This study combines female-lethal alleles with homing gene drive to improve population suppression efficiency while maintaining self-limiting properties in mosquitoes.

This study analyzes spatial suppression gene drive dynamics, finding that larger areas and certain life history traits increase vulnerability to chasing, while resistance mechanisms affect drive performance.

This study identifies first-male sperm precedence in fall armyworms and shows sterile males can suppress pest populations through sperm competition mechanisms.