IL-21-producing peripheral helper T cells associate with autoimmune bile duct injury in biliary atresia
Mengting Liu, Weida Meng, Yuehua Chen, Shaojing Wu, Manning Qian, Di Chen, Jie Zhang, Jianxiang Dong, Yang Yifan, Jingying Jiang, Teng Li, Shi Qx, Xufang Gu, Shaoyang Sun, Wenqing Qiu, , Yun Liu
This study identifies IL-21-producing Tph cells in tertiary lymphoid structures of biliary atresia patients and shows IL-21R blockade reduces disease severity in a mouse model.
bioRxiv · Jul 13, 2026 · PreprintImmunology