Author

Di Chen

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:contrastive learning· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Aaron FerberiD· 1 shared Bart SelmaniD· 1 shared Carla P. Gomes· 1 shared Christopher N. ParkhurstiD· 1 shared David ArtisiD· 1 shared Delia Qu· 1 shared Dieqiao FengiD· 1 shared Frank C. SchroederiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Aaron FerberORCID

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Author profile →

3 papers

Recent·Most cited

Charting the small-molecule universe from mass spectra with neuro-symbolic AI

Utku Umur Acikalin, Dieqiao Feng, Aaron Ferber, Gonçalo J. Gouveia, Tyler J. Schwertfeger, Di Chen, Delia Qu, Marissa A. Fontaine, Yingheng Wang, Richard A. Bernstein, Haofan Wang, Tae-Hyung Won, Christopher N. Parkhurst, Bart Selman, David Artis, , Carla P. Gomes

AIMe uses neuro-symbolic AI to predict and annotate small-molecule spectra, expanding the searchable chemical space by three orders of magnitude.

bioRxiv · Aug 6, 2026 · PreprintBiochemistry

IL-21-producing peripheral helper T cells associate with autoimmune bile duct injury in biliary atresia

Mengting Liu, Weida Meng, Yuehua Chen, Shaojing Wu, Manning Qian, Di Chen, Jie Zhang, Jianxiang Dong, Yang Yifan, Jingying Jiang, Teng Li, Shi Qx, Xufang Gu, Shaoyang Sun, Wenqing Qiu, , Yun Liu

This study identifies IL-21-producing Tph cells in tertiary lymphoid structures of biliary atresia patients and shows IL-21R blockade reduces disease severity in a mouse model.

bioRxiv · Jul 13, 2026 · PreprintImmunology

Bone Mechanosensing Dictates Hematopoietic Stem Cell Fate and Immune Homeostasis

Wuju Zhang, Yating Pan, Xiaoling Xie, Jianmeng Du, Huihui Zhang, Z L Ye, Xiaoqing Yan, 黄炯竑, Hailin Jing, Sheng Zhang, Xiaolin Liu, Di Chen, Ying Liu, Xiao Hong Yu, Xiaochun Bai

This study shows that bone mechanosensing influences HSC fate and immune homeostasis by directing lymphoid or myeloid differentiation through Piezo1-dependent pathways.

bioRxiv · Jul 9, 2026 · PreprintImmunology