Charles G. Eberhart

This study shows that corin, a CoREST inhibitor, reduces ATRT tumor growth, increases differentiation, and extends lifespan in xenograft models.

This study shows that synchrotron-based proton FLASH techniques preserve neurocognitive function in mice, with neuroprotection observed across different delivery methods and dose-rate metrics.

This study shows that mirdametinib and abemaciclib reduce ATRT cell proliferation and extend mouse survival when used together.

This paper develops a zebrafish xenograft model for diffuse midline glioma by transplanting human DMG cells into zebrafish embryos to enable high-throughput drug screening.

This study identifies K784-6195 as a selective cytotoxic compound for NF1-associated high-grade gliomas with ATRX deficiency, showing reduced sensitivity in wild-type ATRX cells and metabolic pathway disruption.