Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system
P. S. Chang, Y.-C. Chen, W.-K. Hua, J. C. Hsu, J.-C. Tsai, Y.-W. Huang, Y.-H. Kao, P.-H. Wu, Y.-F. Chang, M. C. Chang, Y. C. Chang, S.-L. Jian, J.-S. Lai, M.-T. Lai, W.-C. Yang, , S. C.-Y. Wu
This paper demonstrates the efficient manufacturing of CD20/CD19 dual-targeted, iCasp9-regulatable CAR-TSCM cells using the virus-free qCART system, showing robust tumor eradication and safety.
bioRxiv · May 3, 2022 · PreprintCancer Biology