Author

W.-K. Hua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

J. C. Hsu· 3 shared K.-L. K. Wen· 3 shared P. S. Chang· 3 shared S. C.-Y. Wu· 3 shared Y.-C. Chen· 3 shared J.-C. Tsai· 2 shared P.-H. Wu· 2 shared P.-N. Wang· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

J. C. Hsu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Quantum CART (qCART), a piggyBac-based system for development and production of virus-free multiplex CAR-T cell therapy

Y.-C. Chen, W.-K. Hua, J. C. Hsu, P. S. Chang, K.-L. K. Wen, Y.-W. Huang, J.-C. Tsai, Y.-H. Kao, P.-H. Wu, P.-N. Wang, K.-F. Chen, W.-T. Liao, S. C.-Y. Wu

The paper introduces a virus-free multiplex CAR-T cell therapy system called qCART, integrating four platforms to improve CAR-T development and manufacturing.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using qCART, the Quantum pBac-based CAR-T system

P. S. Chang, Y.-C. Chen, W.-K. Hua, J. C. Hsu, J.-C. Tsai, Y.-W. Huang, Y.-H. Kao, P.-H. Wu, Y.-F. Chang, M. C. Chang, Y. C. Chang, S.-L. Jian, J.-S. Lai, M.-T. Lai, W.-C. Yang, , S. C.-Y. Wu

This paper demonstrates the efficient manufacturing of CD20/CD19 dual-targeted, iCasp9-regulatable CAR-TSCM cells using the virus-free qCART system, showing robust tumor eradication and safety.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Quantum pBac: An effective, high-capacity piggyBac-based gene integration vector system for unlocking gene therapy potential

W.-K. Hua, J. C. Hsu, Y.-C. Chen, P. S. Chang, K.-L. K. Wen, P.-N. Wang, Y.-S. Yu, Y.-C. Chen, I.-C. Cheng, S. C.-Y. Wu

This paper develops a virus-free gene therapy vector system, Quantum pBac, which improves transposition efficiency and payload capacity for CAR-T cell production.

bioRxiv · Apr 29, 2022Cancer Biology

State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Leukemia Development

R. C. Rockne, S. Branciamore, J. Qi, D. Frankhouser, D. O'Meally, W.-K. Hua, G. J. Cook, L. Zhang, E. Carnahan, A. Marom, H. Wu, D. Maestrini, X. Wu, Y.-C. Yuan, Z. Liu, , G. Marcucci

The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.

bioRxiv · Jun 4, 2019 · PreprintCancer Biology