Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer
M. Ukita, J. Hamanishi, H. Yoshitomi, K. Yamanoi, S. Takamatsu, A. Ueda, H. Suzuki, Y. Hosoe, Y. Furutake, M. Taki, K. Abiko, K. Yamaguchi, H. Nakai, T. Baba, N. Matsumura, , M. Mandai
This study shows that CXCL13-producing CD4+ T cells induce tertiary lymphoid structures (TLSs) in ovarian cancer, increasing CD8+ T cell and B cell infiltration and improving patient prognosis.
JCI Insight · Jun 22, 2022Peer-reviewedImmunology