H. Suzuki

Differences in factors determining taxon-based and trait-based community structures: a field test using zooplankton

This study compares taxon-based and trait-based community structures in zooplankton using 87 reservoirs, finding environmental factors explain more variation in trait-based structures than spatial factors.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Heart generation via blastocyst complementation in Mesp1/2-deficient mice

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

Inference of Selective Force on House Mouse Genomes during Secondary Contact in East Asia

The paper analyzes 163 house mouse genomes to study selective forces during secondary contact in East Asia, finding genomic admixture and sex chromosome conflict.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

This study shows that Gas6, secreted by intestinal macrophages, prevents K. pneumoniae translocation to the liver in mice, but its reduction in aging allows bacterial invasion and systemic infection.

Identification of basic helix-loop-helix transcription factors that activate betulinic acid biosynthesis by RNA-sequencing of hydroponically cultured Lotus japonicus

The paper identifies LjbHLH32 and LjbHLH50 as transcription factors that activate betulinic acid biosynthesis in Lotus japonicus through RNA-sequencing and functional experiments.

Prophages and plasmids display opposite trends in the types of accessory genes they carry

The paper compares prophages and plasmids in 21 pathogenic bacterial species, finding they carry different frequencies of antibiotic resistance and virulence factor genes.

Childhood cancer mutagenesis caused by a domesticated DNA transposase

This study identifies PGBD5 as a primary mutator in medulloblastoma by showing it drives somatic DNA rearrangements in cerebellar progenitor cells.

Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer

This study shows that CXCL13-producing CD4+ T cells induce tertiary lymphoid structures (TLSs) in ovarian cancer, increasing CD8+ T cell and B cell infiltration and improving patient prognosis.

Nuclear auxin signaling is essential for organogenesis but not for cell survival in the liverwort Marchantia polymorpha

Mutations in OsRZF1, encoding a zinc-finger protein, causes reduced magnesium uptake in roots and translocation to shoots in rice

The paper identifies a rice mutant with reduced magnesium uptake and translocation, linking it to a novel zinc-finger gene OsRZF1 involved in magnesium homeostasis.

Inferring future changes in gene flow under climate change in riverscapes

This study predicts future changes in gene flow for fluvial sculpin under climate change using riverscape genetics and hydrological models.

ILC3s select for RORγt+ Tregs and establish tolerance to intestinal microbiota

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

An ancestral function of strigolactones as symbiotic rhizosphere signals

This study identifies BSB, an ancestral strigolactone in bryophytes, which functions as a rhizosphere signal for AM symbiosis and was later co-opted as a plant hormone.

Versatile live attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

This study develops a live attenuated SARS-CoV-2 vaccine platform using temperature-sensitive mutations that provides protection against homologous and heterologous viral challenges.

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

This study uses single-cell RNA sequencing to identify nine hemocyte subpopulations in shrimp and their differentiation pathways.

Efficient Development of Platform Cell Lines Using CRISPR-Cas9 and Transcriptomics Analysis

The paper develops CRISPR-Cas9 mutants of U87MG cells to create platform cell lines for drug testing, finding that transcriptomic analysis helps identify clones with minimal phenotypic divergence from wild type.

The Arabidopsis NRT1/PTR FAMILY Protein NPF7.3/NRT1.5 is an Indole-3-butyric Acid Transporter Involved in Root Gravitropism

The paper identifies NPF7.3 as an IBA transporter involved in root gravitropism by facilitating IBA uptake, which is necessary for auxin gradient formation.

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

This study reports cryo-EM structures of McrBC complexes from different bacteria, revealing structural asymmetry that governs GTPase activity and nuclease function.

Evolution of olfactory receptors tuned to mustard oils in herbivorous Drosophilidae

This study identifies olfactory receptor paralogs in Scaptomyza flava that detect mustard oils, showing how plant toxins were co-opted as olfactory attractants through gene duplication and functional specialization.

The Effect of Eucalyptol on Nursing Home Residents

This pilot study investigates eucalyptol's effect on dementia symptoms in nursing home residents, finding significant improvements in cognitive and behavioral scores with increased exposure.

Design principles of a minimal auxin response system

The paper identifies a minimal auxin response system in Marchantia polymorpha, showing that a single A-ARF activates gene expression while a B-ARF represses it, defining developmental zones of auxin response.

Cables2 Is a novel Smad2-regulatory factor essential for early embryonic development in mice

This study identifies Cables2 as a Smad2-regulatory factor required for early embryonic development in mice, showing its role in gastrulation and gene expression patterns.

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians

This study identifies an increase in cytotoxic CD4 T-cells and a reduction in B-cells in supercentenarians through single-cell transcriptomics.

AI on animals: AI-assisted animal-borne logger never misses the moments that biologists want

This paper introduces AI-assisted biologgers that use intelligent sensor control to focus data collection on specific target behaviors, improving resource efficiency during long deployments.

OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages

This study identifies OVOL2 as a key factor that induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages.

Extracellular matrix mineralization in the mouse osteoblast-like cell line MC3T3-E1 is regulated by actin cytoskeleton reorganization and non-protein molecules secreted from the cells themselves

This study shows that actin cytoskeleton reorganization and non-protein molecules secreted by MC3T3-E1 cells regulate extracellular matrix mineralization during osteoblast differentiation.

Structural and Functional analysis of the GABARAP Interaction Motif (GIM).

The paper identifies a GABARAP-specific interaction motif (GIM) and demonstrates its selectivity over LC3 using biophysical and structural analyses.

Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus ×- yedoensis 'Somei-yoshino' across the Japanese archipelago

The paper collects and analyzes environmental DNA from petal surfaces of cherry trees across Japan, showing rapid DNA attachment and the presence of other plant DNA, supporting the use of petals for studying environmental DNA dynamics.