H. Nakai

Extensive distribution of β-1,2-glucanases: finding of new glycoside hydrolase families of β-1,2-glucanases

The paper identifies three new glycoside hydrolase families of β-1,2-glucanases and reveals their functional and structural relationships within a superfamily.

Phytopathogenic cyclic glucohexadecaose from an inverting transglycosylase

This study identifies OpgD as the enzyme responsible for synthesizing CβG16, a key virulence factor in Xanthomonas, revealing a novel transglycosylation mechanism with implications for developing new agrichemicals.

Functional and structural analysis of a cyclization domain in a cyclic beta-1,2-glucan synthase

The paper functionally and structurally analyzes the cyclization domain of a cyclic β-1,2-glucan synthase, revealing it produces cyclic β-1,2-glucans through transglycosylation without hydrolysis and proposes it belongs to a new glycoside hydrolase family.

Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids

This study identifies AAV capsids that enhance gene delivery to renal tubules and podocytes, showing context-dependent effectiveness based on delivery route and disease state.

Novel glycoside hydrolase family enzymes from Escherichia coli are associated with osmo-regulated periplasmic glucan synthesis

The paper identifies OpgG and OpgD from E. coli as β-1,2-glucanases with distinct activities, revealing a new glycoside hydrolase family and a unique reaction mechanism for OpgD.

Cleavage of α-1,4-Glycosidic Linkages by the Glycosylphosphatidylinositol-Anchored α-Amylase AgtA Decreases the Molecular Weight of Cell Wall α-1,3-Glucan in Aspergillus oryzae

This study shows that AoAgtA, a GPI-anchored α-amylase in Aspergillus oryzae, cleaves -1,4-glycosidic bonds in the spacer region of cell wall -1,3-glucan, reducing its molecular weight.

Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer

This study shows that CXCL13-producing CD4+ T cells induce tertiary lymphoid structures (TLSs) in ovarian cancer, increasing CD8+ T cell and B cell infiltration and improving patient prognosis.

Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma

This study identifies frequent PIK3CA mutations in eutopic endometrium of ovarian clear cell carcinoma patients, showing high mutation rates and intratumor heterogeneity.

Hydroxide Ion Carrier for Proton Pump in Bacteriorhodopsin: Primary Proton Transfer

This study uses quantum-mechanical simulations to reveal a hydroxide ion mechanism for primary proton transfer in bacteriorhodopsin, showing the role of specific internal water molecules in the process.