Author

Y. Grad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. J. Arnold· 2 shared J. Corander· 2 shared W. P. Hanage· 2 shared A. Dennis· 1 shared C. Wadsworth· 1 shared C. Wiuf· 1 shared D. H. F. Rubin· 1 shared D. W. Eyre· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEvolutionary Biology

B. J. Arnold

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of hidden population structure in time-scaled phylogenies

E. Volz, C. Wiuf, Y. Grad, S. Frost, A. Dennis, X. Didelot

This paper introduces a statistical test to detect hidden population structure in time-scaled phylogenies and applies it to HIV-1 and Neisseria gonorrhoeae data to identify outbreaks and antimicrobial resistance patterns.

bioRxiv · Jan 10, 2020Evolutionary Biology

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

S. G. Palace, Y. Wang, D. H. F. Rubin, M. Welsh, T. D. Mortimer, K. Cole, D. W. Eyre, S. G. Walker, Y. Grad

The paper identifies RNA polymerase mutations in Neisseria gonorrhoeae that confer ceftriaxone resistance independently of penA mutations.

bioRxiv · Aug 28, 2019Microbiology

Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen

B. J. Arnold, M. Sohail, C. Wadsworth, J. Corander, W. P. Hanage, S. Sunyaev, Y. Grad

The paper identifies strong signatures of positive selection in Neisseria gonorrhoeae by analyzing fine-scale haplotype structure and linkage patterns between nonsynonymous alleles.

bioRxiv · May 10, 2019Evolutionary Biology

Weak epistasis may drive adaptation in recombining bacteria

B. J. Arnold, M. Gutmann, Y. Grad, S. K. Sheppard, J. Corander, M. Lipsitch, W. P. Hanage

This study shows that weak epistasis can influence adaptation in recombining bacteria, even when recombination is frequent, due to limited transfer of genetic segments.

bioRxiv · Mar 23, 2017Evolutionary Biology