Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
Y. Hikichi, R. Van Duyne, P. Pham, J. L. Groebner, A. Wiegand, J. W. Mellors, M. F. Kearney, E. O. Freed
This study shows that HIV-1 envelope glycoprotein mutations can confer broad antiretroviral resistance through cell-cell transmission and structural changes, independent of target-gene mutations.
bioRxiv · Aug 6, 2020Microbiology