Core-2 O-glycans are required for Galectin-3 interaction with the osteoarthritis related protein lubricin
S. A. Flowers, K. A. Thomsson, L. Ali, S. Huang, Y. Mthembu, S. C. Regmi, J. Holgersson, T. A. Schimdt, O. Rolfson, L. I. Bjorkman, M. Sundqvist, A. Karlsson, G. D. Jay, T. Eisler, R. Krawetz, N. G. Karlsson
The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.
bioRxiv · Dec 20, 2019Biochemistry