Lysosomal microautophagic pathway links proteostasis to protein aggregation disease
Y. Fujiwara, C. Kabuta, V. R. Contu, M. Ogawa, H. Fujita, H. Kikuchi, R. Sakai, M. Suzuki, I. Koyama-Honda, M. Inoue, Y. Oya, Y. U. Inoue, T. Inoue, R. Takahashi, G. Matsumoto, , T. Kabuta
This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.
bioRxiv · Aug 11, 2020 · PreprintCell Biology