H. Fujita

High-throughput screening for Cushing's disease: therapeutic potential of thiostrepton via cell cycle regulation

This study identifies thiostrepton as a potential therapy for Cushing's disease by inducing cell cycle arrest in PitNETs through mechanisms independent of FOXM1.

Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone

This study analyzes the transcriptome of hyperthyroid mice overexpressing TSH, identifying novel genes and pathways associated with goiter development and thyroid hormone secretion.

HOIL-1L deficiency induces cell cycle alteration which causes immaturity of myocyte and fibrogenesis

This study shows HOIL-1L deficiency leads to cell cycle defects and fibrosis in myotubes and cardiomyocytes, contributing to myopathy and dilated cardiomyopathy.

Soil Prokaryotic and Fungal Biome Structures Associated with Crop Disease Status across the Japan Archipelago

The paper analyzes soil microbiome structures across Japan to identify microbial species sets associated with crop disease prevalence and suggests key microbes for managing disease-suppressive agroecosystems.

Deterministic and stochastic processes generating alternative states of microbiomes

The paper shows that deterministic and stochastic processes drive divergence into alternative microbiome states in experimental settings.

Facilitative interaction networks in experimental microbial community dynamics

The paper analyzes facilitative interactions in microbial communities using metagenomic data and metabolic modeling to identify feedback loops and keystone species.

Metagenomic analysis of ecological niche overlap and community collapse in microbiome dynamics

The paper uses metagenomic analysis to study how genetic resource-use profiles influence community collapse in microbiomes over time.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation

This paper develops a method to estimate crossbridge-state in cardiomyocytes using SHG polarization, showing its applicability in assessing myosin force generation and drug effects.

Core species and interactions prominent in fish-associated microbiome dynamics

The paper identifies core microbial species and interactions in fish-associated microbiomes using time-series data and network analysis.

Silicon as a microfluidic material for imaging and incubation of droplets

This paper demonstrates that silicon chambers improve droplet imaging and incubation by enhancing optical, thermal, and mechanical properties compared to PDMS.

Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics

This study shows that abrupt microbiome changes can be predicted using ecological concepts and stability indices in complex microbial communities.

Basins of attraction of microbiome structure and soil ecosystem functions

The paper investigates basins of attraction in soil microbiome structure and their associations with ecosystem functions and crop disease prevalence.

Single-molecule tracking of Nanog and Oct4 in mouse embryonic stem cells

The paper tracks Nanog and Oct4 in mouse embryonic stem cells to study their roles in pluripotency, finding that Nanog interacts longer with targets during differentiation, suggesting a feedback mechanism.

Mice generated with induced pluripotent stem cells derived from mucosal-associated invariant T cells

The paper generates mice with MAIT cell-specific TCRs to study their function, finding differences in cancer resistance between two mouse models.

Reprogramming and redifferentiation of mucosal-associated invariant T cells reveals tumor inhibitory activity

The paper reprograms and redifferentiates murine MAIT cells into m-reMAIT cells to study their tumor inhibitory activity, showing they enhance survival via NK cell-mediated cytotoxicity.

Synergistic and offset effects of fungal species combinations on plant performance

The paper evaluates how combinations of fungal species affect plant performance, finding that synergistic and offset effects are common, and single-species inoculations may misrepresent microbial impacts in multi-species contexts.

MARCH8 targets cytoplasmic lysine residues of various viral envelope glycoproteins

This study identifies MARCH8 as an antiviral factor that ubiquitinates and degrades viral envelope glycoproteins by targeting their cytoplasmic lysine residues.

Lysosomal microautophagic pathway links proteostasis to protein aggregation disease

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

MARCH8 inhibits viral infection by two different mechanisms

This study identifies two distinct mechanisms by which MARCH8 inhibits viral infection: ubiquitination of VSV-G and tyrosine motif-dependent sorting of HIV-1 Env.

Two-way migration of Lychnis wilfordii caused by the circular landform of Japan-Korea-northeast China-Russian Far East region and its suggestion for conservation in northeast Asia

This study investigates the genetic structure and migration routes of Lychnis wilfordii across northeast Asia, suggesting conservation strategies based on its evolutionary history.

Serpentine mountain uplift in northern Japan triggered the divergence of a narrow endemic from a widespread (sub)arctic Asia-Alaska species complex of Lagotis (Plantaginaceae)

The paper investigates the divergence of two narrow endemic Lagotis species in northern Japan from a widespread (sub)arctic Asia-Alaska species complex, linking it to mountain uplift and ecological factors.